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Conversely, reducing KYNA through targeted KAT deletion enhances hippocampal glutamatergic tone, improving cognitive performance and synaptic plasticity [30]

Endometriosis involves significant fibrosis, and anti-fibrotic effects could theoretically reduce adhesion formation and tissue scarring that contributes to pain and organ dysfunction

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Studies demonstrate that NSAIDs increase upper gastrointestinal bleeding risk 2-4 fold in the general population, and this risk amplifies when combined with medications that alter gastric function like semaglutide