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Therefore, to test the assumption that GSH replenishment will rescue some of the AS cellular phenotypes, we supplemented the AS and the WT NPCs cell culture with GSH-EE, and first showed that GSH-EE increased the GSH levels in AS NPCs to normal WT NPCs levels, but did not significantly enhanced GSH levels in WT NPCs (Fig

These differences were reported for all parameters investigated (Kalidindi et al., 2024)

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When the antioxidant glutathione is administered intravenously, this causes an immediate boost in energy since the antioxidant is known to enhance mitochondrial energy production in cells