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doi: 10.1016/j.tox.2024.153958 61 PalombaSPiltonenTTGiudiceLC

Stoichiometry of the TCA Cycle The overall stoichiometry of the TCA cycle is: acetyl-CoA + 3NAD + + FAD + GDP + P i + 2H 2 O 2CO 2 + 3NADH + FADH 2 + GTP + 2H + + CoASH Role of Lactate as Driver for TCA Cycle Activity The lactate produced by anaerobic glycolysis does not simple serve as an intracellular carbon source for hepatic glucose production via gluconeogenesis

In several European countries, this is an official indication for treatment

Weight management : Modest weight loss (5-10% of body weight) in individuals with overweight or obesity can improve metabolic parameters and potentially enhance endogenous GLP-1 activity

Patients report feeling satisfied with smaller portions and experiencing fewer food cravings