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The significance of IDH1 and IDH2 produced NADPH can be made clear by pointing out that cells with low level IDH1 and IDH2 expression are more sensitive to oxidative stress than cells with higher levels of expression of these two enzymes
Because the body does not produce B12 naturally, maintaining healthy levels through diet or supplementation is essential
There could be a variety of reasons
However, upward migration of melanocytes on its own is not diagnostic of malignancy as this feature may be seen in variants of nevi-like lesions occurring at some special sites (see below)
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