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Human data: two healthy adults tolerated 20 mg IV without adverse events (Lee & Burgess, 2025) the only formal human safety data

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Clinical trial data shows increased incidence of biliary disease, likely related to rapid weight loss and altered bile composition during metabolic changes

If you are obese (body mass index 30 kg/m or greater) or overweight (BMI 27 kg/m or greater) with at least one weight-related health condition, such as high blood pressure, heart disease, or high cholesterol levels, you are eligible to use semaglutide

All GLP-1 analogs significantly or slightly reduced plasma AST, ALT, TG, TC, insulin, and HOMA-IR levels (Fig