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For suspected cardiac causes, BNP or NT-proBNP testing may be helpful, while D-dimer and CT pulmonary angiography may be indicated when pulmonary embolism is suspected

One exception is in addiction, where VPAT knockout mice have been shown to be more sensitive to amphetamine and less sensitive to diazepam, suggesting a role for Spd/Spm co-transmission (Fredriksson et al., 2019)