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The turning point came around 2015, when higher-dose liraglutide, under the brand name Saxenda, was approved for obesity, confirming the weight loss effect wasnt just a side effect, but a primary therapeutic action. GLP-1s worked differently from earlier diet drugs

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At the 12mg dose: 58.6% of participants lost 25% or more of their body weight 39.4% of participants lost 30% or more Those thresholds are typically associated with bariatric surgery

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