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These drugs mimic the physiological effects of GLP-1 by binding to GLP-1R, which enhances insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces food intake (Figure 1B)

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In the SUSTAIN 7 40-week trial, 1,201 adult patients with type 2 diabetes mellitus and an HbA1 7 or greater were given either a 0.75 mg or 1.5 mg dose of Trulicity or a 0.5 mg or 1 mg dose of Ozempic

However, severe, recurrent, or widespread bruising warrants medical review to exclude underlying clotting disorders

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