In this blog from PharmaLabGlobal explore whether peptides, commonly used for fitness and therapeutic purposes, are detectable in drug tests
The outcomes were liver biopsy-based (NAFLD activity score [NAS], fibrosis stage, and NASH resolution), noninvasive technique-based (liver fat content on proton magnetic resonance spectroscopy [ 1 H-MRS] and controlled attenuation parameter [CAP]), biological, and anthropometric indicators
In the study SCALE (Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE - Obesity and Pre-diabetes), patients with obesity and pre-diabetes were randomized to once-daily subcutaneous injections of liraglutide at a dose of 3.0 mg or placebo
This suggests that future regulatory applications could push the approved dose ceiling higher for patients with severe obesity who need more aggressive intervention
Kidney problems can also occur or worsen if vomiting or diarrhea leads to dehydration