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Although GLP-1RAs can reduce body weight by 15%25% in controlled settings, real-world adherence is limited, and nearly 70% of patients experience weight regain after discontinuation, raising the risk of long-term pharmacological dependence ( Looking ahead, the future of GLP-1based therapy will depend on addressing safety concerns, improving long-term adherence, and expanding clinical indications

Its ability to modulate the hepatocyte growth factor (HGF)/c-Met system provides a functional platform for exploring molecular events underlying cognitive processes

-4 DPP-4 -4 .241 GLP-1(936) -

Psychoneuroendocrinol 46:14-22, 2014

The agency also warns that certain substances, including retatrutide and cagrilintide, cannot legally be used in compounding and have not been proven safe or effective for any condition