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Integrating these exercise strategies with nutritional support is essential to preserve muscle mass, reduce fatigue, and maximize the benefits of GLP-1RA therapy ( Table 1 Physical activity recommendations in people with obesity on GLP-1RAs

Limitations: Gastrointestinal adverse effects, particularly nausea and vomiting, were common and contributed to relatively high dropout rates

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85 Serial studies from the US and Europe suggest that energy expenditure from physical activity increased between 1981 and 2017, during the onset of the obesity epidemic, while basal metabolic expenditure declined, implicating other factors such as dietary composition that impact metabolic rate

Finally, avoid skipping meals and eliminate sugar-sweetened beverages