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Moreover, FOXO4-DRI was used to selectively induce apoptosis of senescent fibroblasts in both keloid fibroblast and organ culture senescent models, showing potential as a treatment that targets the senescence and apoptosis resistance observed in keloid fibroblasts

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The relative expression levels of each gene were quantitated using the 2 CT method and normalized to the amount of endogenous glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

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