D.StankovK.InjacR.DjordjevicA.SrdjenovicB.GovedaricaB.et al (2009)
The lyophilisation process removes water, eliminating the solvent that would otherwise allow hydrolysis reactions to degrade the peptide backbone
doi: 10.3389/fcell.2025.1623959 Received 06 May 2025 Accepted 04 August 2025 Published 20 August 2025 Volume 13 - 2025 Edited by Valerie Kouskoff, The University of Manchester, United Kingdom Reviewed by Soumya Ranjan Jena, Ravenshaw University, India Vinod Reddy Lekkala, University of California, San Francisco, United States Updates Copyright 2025 Feng and He
Glossary AGEs Advanced Glycation End products AMPK AMP-activated protein kinase Arg1 Arginase 1 ASC Apoptosis-associated speck-like protein containing a CARD ATP Adenosine Triphosphate BA Baicalin BH4 Tetrahydrobiopterin CAT Catalase C-dots Carbon dots cGAS cyclic GMP-AMP Synthase Cyt c Cytochrome c DAMPs Damage-Associated Molecular Patterns DW Diabetic wounds DMM Dimethyl Malonate Drp1 Dynamin-related protein 1 ECM Extracellular Matrix EGF Epidermal Growth Factor EPCs Endothelial Progenitor Cells ETC Electron Transport Chain EVs Extracellular Vesicles Fenton reaction Fenton reaction GPx Glutathione Peroxidase GTP Guanosine Triphosphate HG HyperGlycemia HIF-1 Hypoxia-Inducible Factor 1-alpha IFN Interferon IB Inhibitor of Kappa B Alpha IL Interleukin iNOS inducible Nitric Oxide Synthase IRF3 Interferon Regulatory Factor 3 MAPK Mitogen-Activated Protein Kinase MDA Malondialdehyde Mfn1/2 Mitofusin 1/2 MMPs Matrix Metalloproteinases MOFs Metal-Organic Frameworks MPs Mitochondria-targeted Peptides mPTP mitochondrial Permeability Transition Pore MSCs Mesenchymal Stem Cells mtDNA mitochondrial DNA mtROS mitochondrial Reactive Oxygen Species NF-B Nuclear Factor Kappa B NLRP3 NLR Family Pyrin Domain Containing 3 NO Nitric Oxide Nrf2 Nuclear factor erythroid 2-related factor 2 OPA1 Optic Atrophy 1 OXPHOS OXidative PHOSphorylation PDGF Platelet-Derived Growth Factor PHD Prolyl Hydroxylase PINK1 PTEN-induced Kinase 1 RAGE Receptor for AGEs ROS Reactive Oxygen Species SDH Succinate Dehydrogenase SIRT1 Sirtuin 1 SOD Superoxide Dismutase STING Stimulator of Interferon Genes TCA Tricarboxylic Acid TGF- Transforming Growth Factor-Beta TIMPs Tissue Inhibitors of Metalloproteinases TNF- Tumor Necrosis Factor-Alpha TPP+ Triphenylphosphonium VEGF Vascular Endothelial Growth Factor m Mitochondrial Membrane Potential References 1 AkterS.AhmadS
We reasoned that the strong avidity of the FA-carbonyl group toward electron-rich thiol groups might affect the antioxidant GSH
