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Glucagon receptor activation is thought to increase energy expenditure and promote fat breakdown (lipolysis), which may help explain the substantial weight loss observed in early-phase trials however, these mechanistic effects have not yet been fully characterised in humans and should be regarded as preliminary findings

Neural Regen Res 13:15071515

Some users who have been off treatment and want to resume should review the guidelines for restarting semaglutide after a break , as dosing protocols may differ from the initial start

Brito-da-Costa AM, Dias-da-Silva D, Gomes NGM, Dinis-Oliveira RJ, Madureira-Carvalho