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Yes, semaglutide may stop working or become less effective over time, a phenomenon known as the plateau phase

What Patients Consider With Low-Dose Semaglutide Below FDA-approved dose Weekly doses below the FDA-approved starting dose of 0.25 mg have not been tested in a randomized controlled trial and are not endorsed by the manufacturer

Do the patient noticed any lump elsewhere

Boots has been contacted for comment.

Interestingly, higher incidence of diabetic retinopathy (DR) complications was noted in patients taking semaglutide (3.0%) compared to placebo (1.5%) in clinical trials, with greater risk in those with a history of DR [32]