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RAW264.7 macrophages exposed to 50 g/mL oxLDL for 24 h displayed substantial intracellular lipid droplet accumulation and noticeable foam cell formation, as confirmed by Oil Red O (ORO) staining of the lipid droplets (Fig

They primarily exert metabolic integration functions through activation of the nuclear receptor farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor 5 (TGR5) ( FXR is widely expressed in the liver and intestine and serves as a feedback sensor for bile acid synthesis

Early healing response underway

Although several studies now recognize these reprogrammed activities as hallmarks of cancer, it remains unclear which are the pathways involved in regulating metabolic plasticity

Wang C, Kahle ER, Li Q, et al