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In all clinical trials, participants who lost the most weight paired medication with intensive diet and exercise modifications

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Effects of resistance exercise training on oxidative stress and inflammation Chronically elevated oxidative stress and diminished antioxidant defenses causes neuronal damage and mitochondrial dysfunction, which play key roles in neurodegenerative pathologies (Guo et al., 2013)

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Work with your clinician to optimize the dose ramp, slow the weekly loss rate if feasible , and screen for correctable deficiencies