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Despite their utility, a significant challenge in iHLO research lies in determining the optimal developmental timepoints for liver-like functionality, which is critical for their effective use in pharmacological and toxicological studies
doi: 10.4161/cbt.4.10.2184 127 LiHJiaYWangY
They played a role in anti-inflammation, anti-oxidation, and neuroprotection (Sagit et al., 2017)
LEADER Trial The renal outcome in this trial was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease
Active concentrations are typically in the nanomolar to micromolar range depending on the study and assay system
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