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Evidence sources: pivotal phase 3 trials (e.g., SURMOUNT-1), extensions and subgroup analyses, mechanistic papers on GIP/GLP-1 dual agonism, and expert consensus statements

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Beyond pancreatic -cells, GLP-1R is also found on various other cell types, such as neuronal cells, cardiovascular cells, gastrointestinal smooth muscle cells, and immune cells [10,11,12,13,14,15,16,17] (Fig

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