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Independent HTS assessments of data generated by ToxCast and Tox21 in relation to metabolic disruption have found these to be inadequate with respect to reliability (160), and whilst there is great utility in HTS for the purposes of prescreening, for (pre)validation purposes with respect to the objective of the current exercise, they were not considered to contribute substantially to the WoE

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Or in some cases, they may recommend reducing your dose back to the previous amount if youre having trouble tolerating the increase

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doi:10.1016/j.tox.2007.10.011 Raza H (2011) Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease