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21 compounds were identified by mass spectrometry and ranked by their potential ability to inhibit ALOX-5 and HDC gene expression in silico, and suggested Luteolin as a strong candidate for modulation of mast cell activation

From an interventional standpoint, modulating the gut microbiota or its metabolic pathways could represent a potential adjunctive therapeutic approach

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These results indicated that T7-LNP@YHV984 not only promoted the polarization of microglia toward the M2 type to inhibit the progression of inflammation, but also regulated intracellular redox homeostasis