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In the case of UreG, this creates a subunit-bridging Ni II site that is coordinated by an invariant Cys -Pro- His sequence from opposite protomers and positioned between the G2 and G3 loops in the primary structure, to form an approximately square planar Cys 2 -His 2 coordination complex (Figure 38A), 822 mutagenesis of which abolishes urease maturation

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As a result, symptoms of B12 deficiency can vary considerably, both in symptom type and severity

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