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Methods Pediatric oncology patients (n=100) completed PROMIS Pediatric item banks for Anxiety v3.0, Depressive Symptoms v3.0, Peer Relationships v3.0, Mobility v3.0, Fatigue v3.0, and Sleep Disturbances v1.0, as well as Global Health v1.0 scale, Anger 9a v3.0 short form, and Pain Intensity item v1.0

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0 mg, orlistat, phenterminetopiramate, and naltrexonebupropion for weight loss efficacy Pharmacokinetic Profile Route of Administration SC Dosing Frequency Once weekly Half-Life 184 hours Route of Administration : Subcutaneous Dosing Frequency : Once weekly (subcutaneous) Half-Life : ~155184 hours (6.57.7 days), supporting once-weekly SC dosing Formulation : Formulation & Handling Reconstitute in sterile water or PBS (pH ~7.4) for in vivo/in vitro use Store at 20C in aliquots to prevent freeze-thaw degradation Shelf-stable for 12 months under recommended storage condition Clinical Trial Activity References Quality & Purity This product is synthesized via solid-phase peptide synthesis (SPPS) and tested to 99% purity by HPLC with identity confirmed by mass spectrometry