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A: No, it does not show direct cause-and-effect

doi: 10.1155/2016/1575130 PMID: 27247935 Katzung BG (2024): Drugs used in heart failure (Chapter 13)

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Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

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