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Semaglutide, marketed as Ozempic, Wegovy, and Rybelsus, is a GLP-1 receptor agonist approved by the FDA for type 2 diabetes and chronic weight management

Kaiser Northwest, for example, requires: (1) documented diet and exercise program, (2) failure of at least 2 weight loss medications (phentermine, Qsymia, Contrave, etc.), AND (3) a minimum 6-month trial of semaglutide (Wegovy or Ozempic) that was ineffective or not tolerated

A medical provider should review your health first

The principal mechanism of protraction resulting in the long half-life of semaglutide is albumin binding, which results in decreased renal clearance and protection from metabolic degradation

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