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4 Phenolic compounds: biosynthesis, regulation, and functional roles 4.1 Biosynthetic origins via the Shikimate pathway Plant secondary metabolites fall into three major biosynthetic categories: phenolic compounds, encompassing phenolic acids, coumarins, stilbenes, lignans, flavonoids, tannins, and lignins

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The tradeoff can be gastrointestinal side effects, especially during dose increases, so pacing and food choices matter

for example, blood pressure treatments have been linked to similar concerns in some patients, including amlodipine-related shedding