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Allosteric modulation, the activation or modulation of a receptor through a site distinct from the endogenous ligand binding site, had been successfully exploited for class A and class C GPCRs but was largely unexplored for class B receptors

The study, presented at the European Congress on Obesity, found that even for those taking newer, higher-dose weight loss drugs such as Wegovy and Mounjaro, people put weight back on once they stopped treatment

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