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Obesity and sleep disturbance: the chicken or the egg

Document baseline health metrics (e.g., weight, A1C, glucose) and consult a healthcare provider

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The epigenetic action of vitamin C has also been evaluated during the gene reprogramming of human fibroblasts to induced pluripotent cells (IPSCs), where it has been shown that vitamin C substantially improves the efficiency and quality of reprogrammed cells compared to other antioxidants and that both processes depend on the action of Fe 2+ /-KGDDs activated by vitamin C (Wang et al., 2011

From day 1 to 3, cells were cultured in StemPro34 SFM (Invitrogen) with 50 g ml 1 ascorbic acid (AA) (Sigma), 2 mM Gluta-MAX (Invitrogen), 10 ng ml 1 BMP4, and 10 ng ml 1 human recombinant activin-A (Invitrogen)