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La American Diabetes Association (ADA) en sus Estndares de Atencin Mdica en Diabetes y el American College of Physicians (ACP) no incluyen parches transdrmicos en sus guas de prctica clnica, ya que carecen de aprobacin regulatoria y evidencia de eficacia

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Le Roux CW, Astrup A, Fujioka K, Greenway F, Lau DC, Van Gaal L, Ortiz RV, Wilding JP, Skjth TV, Manning LS

[56] However, fair credit for the first description of Graves' disease goes to the 12th-century Persian physician Sayyid Ismail al-Jurjani, [57] who noted the association of goiter and exophthalmos in his Thesaurus of the Shah of Khwarazm , the major medical dictionary of its time