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The way I see this playing out, especially with who is appointed to the panel

It further highlighted that lower CSF levels of Vit B12 correlated with higher UPDRS walking item (Christine et al

You can be in very good health and have excess weight, she says

We track your subjective progress (satiety, energy levels, weight loss) and assess your objective biomarkers to plan the next stepwhether that's a dosage increase, a maintenance phase, or a transition to long-term metabolic optimization

If that system is already running at 95% capacity (as it often is in your early 20s), there's less room for optimization than if it's running at 60-70% (more common in your late 30s+)