These medications are another reminder that obesity is a complex chronic disease influenced by biology, genetics, medications, sleep, stress, food environments, and social factors
Despite this improvement, patients may still encounter short-term delays as pharmacies restock
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Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram
Contrary to common knowledge, patients in the subgroup with a higher BMI did not show significant weight gain (WMD = 1.21 kg, 95% CI 1.24 to 3.60, P = 0.33, I 2 = 72%) and there were no significant differences between the subgroups ( P = 0.73) (Additional file 2: Fig
