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Most gastrointestinal side effects of tirzepatide, including nausea and diarrhea, are most severe during the first few weeks of treatment or after dose increases and typically diminish within several days to weeks as the body adapts to the medication

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Many clients experience reduced cravings and increased fullness after meals, though this varies

Pruritus accompanied by jaundice (yellowing of skin or eyes), dark urine, or light-colored stools could indicate gallbladder or liver complications and requires prompt evaluation with appropriate testing