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Novel mesoporous silica-based antibiotic releasing scaffold for bone repair

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Side effects such as nausea, bloating, constipation and fatigue can limit dose escalation, which may reduce the overall effectiveness of treatment for some patients

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It has indeed been demonstrated that p300/CBP transcriptional co-activator proteins (two central players in coordinating and integrating multiple signal dependent events with the transcription apparatus [215, 216]) bind to NRF2 in response to OS induced by arsenite and acetylate several Lys residues within the Neh1, the DNA binding region of NRF2, stabilizing it, increasing protein abundance, and promoting NRF2 nuclear localization [146, 214, 217] (Fig

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