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ROS is a key factor leading to mtDNA leakage, and inhibition of oxidative stress contributes to reduction of mitochondrial damage, release of dsDNA, and activation of AIM2 (176)

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Research suggests supplementing with zinc may help improve sleep quality, while magnesium helps activate your parasympathetic nervous system, which helps the brain and body relax before you fall asleep ( Magnesium appears to help regulate melatonin, a hormone that regulates your sleep-wake cycles, and bind to gamma-aminobutyric acid (GABA) receptors, which plays a role in slowing down nerve activity ( An 8-week study in 43 people with insomnia found that taking the combination of zinc, magnesium, and melatonin before bedtime improved sleep quality and reduced the time to sleep, compared with placebo treatment ( May support immunity Zinc, magnesium, and vitamin B6 have properties that may help support immunity

Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men