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The effects of GLP-1 are mediated through its binding to the GLP-1 receptor (GLP1R)

Individuals with this genotype do not produce functional GSTM1, leading to impaired detoxification capacity and accumulation of acrolein and phosphoramide mustards

Does the cardiac safety signal in the Xu 2023 paper (improved EF in mouse heart failure, no pathological hypertrophy) hold up in healthy human cardiac tissue under chronic exposure alongside a triple-agonist

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