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In men, this mechanism operates independently of sex hormones, making efficacy profiles nearly identical between genders when dosing is appropriately calibrated

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Common scenarios: rheumatoid arthritis, lupus, severe asthma maintenance, post-transplant

The most commonly reported side effects of retatrutide in clinical trials are gastrointestinal, including nausea, vomiting, diarrhoea, constipation, and decreased appetite, consistent with other GLP-1-based therapies

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