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The primary, evidence-based interventions for GLP-1 constipation are established in the broader constipation literature and recommended by clinicians: adequate fluid intake, gradually increased soluble fiber such as psyllium husk, regular physical activity, and osmotic laxatives such as polyethylene glycol when lifestyle measures are insufficient

TMAO and atherosclerosis Atherosclerosis, which is the major risk factor of CVDs, is characterized by foam cell formation, inflammatory cell recruitment, and endothelial dysfunction ( Figure 3 )

REDEFINE 3 cardiovascular outcomes trial is ongoing (~7,000 participants)

Week 2: Sustained hunger reduction

Community Care Plan, a Broward County-based plan, is offering $20 gift cards to members who are willing to receive at least one vaccine dose