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(2025) showed tirzepatide improved endogenous testosterone, SHBG, LH, FSH, and erectile function beyond what TRT or lifestyle alone achieved

The 56-year-old woman in the PMC case report saw resolution after six weeks of continued use

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Furthermore, the translocation to the plasma membrane of 78-kDa glucose-regulated protein GRP78, which facilitates M2 macrophage polarization of TAMs and tumor growth in lung cancer, was induced by IGF-1R signaling, and concomitant IGF-1 blockade and GRP78 knockdown in TAMs suppressed M2 macrophage-induced maintenance, proliferation, and migration of lung cancer cells (27)