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Delayed Relief: As mentioned, the onset of action (the time it takes to feel the drug work) will likely be longer

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This limitation is, however, mitigated by the recent findings of Lamont et al [8] who, using transgenic overexpression of Glp1r in beta cells of Glp1r- null mice, clearly established the critical role of the beta cell GLP-1 receptor (GLP1R) in mediating the beneficial effects of GLP-1 on glucose homeostasis