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Antioxidant Defense: The tartrate portion of the drug acts as a powerful antioxidant

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doi: 10.1146/annurev-med-112311-083918 152 WangWGreenMChoiJEGijonMKennedyPDJohnsonJKet al

Clinicians should be alert to warning signs such as: Rapid increase in lesion size Ulceration or bleeding Color variation or asymmetry Bone destruction or tooth mobility Persistent oral swelling or nodular masses Differential diagnosis includes physiologic pigmentation, melanotic macules, amalgam tattoos, melanocytic nevi, and vascular lesions