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Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor-B activation resulting in antioxidation

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5-Amino-1MQ is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in methylation and NAD+ metabolism

doi: 10.1016/j.pharmthera.2008.09.005 157 WangQHolstJ

Cell culture Human malignant melanoma (A375) cells were obtained from the American Type Culture Collection (ATCC, CRL-1619IG-2) and used within ten passages for all experiments