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liver glucose production decreases22 and intestinal glucose uptake increases, acting as a hyperglycemia clearance mechanism in diabetes.23 The effect of metformin on body weight is neutral, though in some cases it induces modest weight loss.24 While it is a safe drug, its gastrointestinal side effects appear to be underestimated in the literature.4 Gradual dose titration and administration with food is advised in order to improve tolerance of this drug
For researchers using oral capsules, taking the compound 30 to 60 minutes before meals in a fasted state may enhance fat oxidation effects, though this recommendation is based on theoretical considerations rather than controlled studies
