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Drenning JA, Lira VA, Soltow QA, Canon CN, Valera LM, Brown DL, Criswell DS

Increasing too quickly may worsen side effects

MS primarily occurs in intracranial structures, posterior nerve roots of the spinal canal, and less common are seen in sympathetic chain, acoustic nerve, cerebellum, orbit, choroid plexuses, soft tissue, heart, oral cavity, esophageal wall, stomach, colon, bronchus, retroperitoneum, uterine cervix, and parotid gland [3]

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Open-access manufacturer platforms raise concerns about volume growth, inappropriate prescribing and drug waste, which could offset price reductions, she said