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with type 2 diabetes: 62.7% responders and 37.3% non-responders) ( However, the development of newer drugs like tirzepatide offer hope for improved outcomes ( To explore the role of genetic predictors, recent research pooled data from seven major lifestyle intervention trials (NUGENOB, DIOGenes, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, PREDIMED-PLUS)

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This means the compound hits two receptors simultaneously, maximizing appetite suppression and fat metabolism where the single GLP-1 signal can eventually face resistance or regulatory limits and fall short

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Since its initial approval in 2017, semaglutide has been found to worsen existing diabetic retinopathy (DR) in diabetic patients following a drop in their blood glucose (blood sugar control)