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Plasma and liver FGF21 participates in the GCGR mAb-mediated regulation of beta cell identity in vitro Activation of FGF receptor (FGFR) by FGF21 is dependent on the transmembrane protein -klotho (KLB), and the function of FGF21 is mediated mainly via FGFR1c/KLB and FGFR3c/KLB [21,22,23]

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