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Blood Sugar Fluctuations and Their Contribution to Hot Flashes in Menopausal Women, Diabetes Care Journal

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For women, the 2022 Menopause Society (formerly NAMS) position statement acknowledges that compounded bioidentical hormones may be appropriate when FDA-approved products do not meet a patient's specific clinical needs, such as allergy to an inactive ingredient or a required dose not commercially available [6]

We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss

That does not mean split dosing cannot work