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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1

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Other potential DILI biomarkers under investigation include high-mobility group protein B1 (HMGB-1), a nuclear protein released during necrosis, and the ratio of cleaved to full-length cytokeratin [72]

Nat Rev Mol Cell Biol 22:445464 Desnoyers S, Kaufmann SH, Poirier GG (1996) Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors

Helminth infection and commensal microbiota drive early IL-10 production in the skin by CD4 + T cells that are functionally suppressive