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GIP is another crucial incretin hormone that, in addition to enhancing insulin secretion, also appears to play a role in energy balance and how the body metabolizes and stores fat

Because of an increased risk of diabetic ketoacidosis ketone monitoring in patients with type 1 diabetes and in others at risk for ketoacidosis (patients with type 2 diabetes on insulin therapy) should be considered, particularly when precipitating conditions for diabetic ketoacidosis occur such as acute febrile illness, reduced caloric intake, ketogenic diet, surgery, insulin dose reduction, volume depletion, or alcohol abuse

If a clinically significant hypersensitivity reaction occurs, institute appropriate therapy and discontinue DUPIXENT [see Adverse Reactions (6.1, 6.2) and Clinical Pharmacology (12.6)]

This compensation can increase heart rate and renin levels, limiting BP reduction