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Recent studies suggest that bariatric surgery, even though it has higher upfront costs, may be a better deal in the long run

The primary endpoint was predominantly driven by a reduction in CV death (HR 0.73, 95% CI 0.540.99) (Fig

Additionally, more compounds make it harder to isolate which one is responsible for any observed benefit (or harm)

Ann Intern Med 165:305315 Idilman R, Mizrak D, Corapcioglu D et al (2008) Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis