retatrutide clinical trials phase 3 A Study of (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3) Lilly's triple agonist, retatrutide, delivered

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Trends in Pharmacological Sciences , 39(3), 185-194

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In addition to a number of circumventricular organs [CVOs, e.g., median eminence (ME), area postrema (AP), subfornical organ, organum vasculosum of lamina terminalis], liraglutide was also observed in the hypothalamus [arcuate nucleus (ARC), paraventricular nucleus (PVN), supraoptic NTS, supraoptic decussation], which would have necessitated its uptake across the bloodbrain barrier